Professional Monographs
Comprehensive clinical information for healthcare professionals
Popular:
Breastfeeding
Conditions
Consumer Info
Dosage-
Professional Reference
This section contains detailed clinical information intended for healthcare professionals. For patient-friendly information, please refer to our Consumer Drug Information section.
-
Clinical Pharmacology
- Mechanism of Action
Armodafinil enhances wakefulness by increasing dopamine levels via dopamine transporter inhibition and modulating orexin, histamine, and norepinephrine pathways in the brain.
- Pharmacokinetics
Absorption:
Well absorbed. Tmax: 2 hours
Distribution:
Vd ≈ 42L. Protein binding ~13%
Metabolism:
Hepatic via CYP3A4
Elimination:
T½: 15 hours. Primarily renal
-
Indications & Usage
- Narcolepsy
- Obstructive Sleep Apnea (OSA)
- Shift Work Sleep Disorder (SWSD)
-
Contraindications
- Cardiovascular: Avoid in uncontrolled hypertension or heart disease.
- Psychiatric: Not for severe anxiety, psychosis, or bipolar disorder.
- Allergy: Contraindicated in Armodafinil hypersensitivity cases.
-
Warnings & Precautions
- Severe Skin Reactions: Stop use if rash, blisters, or peeling occur.
- Allergic Reactions: Seek help for swelling, breathing issues, or hives.
- Psychiatric Symptoms: Discontinue if anxiety, agitation, or hallucinations appear.
-
Dosing & Administration
Narcolepsy
150 mgOnce daily in the morning
Maximum daily dose: 250 mg
Obstructive Sleep Apnea (OSA)
150 mgOnce daily in the morning
Maximum daily dose: 250 mg
Shift Work Disorder (SWD)
150 mgOne hour before work shift
Maximum daily dose: 150 mg
-
Monitoring
- Cardiovascular: Monitor blood pressure and heart rate regularly.
- Psychiatric: Watch for mood changes, anxiety, or hallucinations.
- Dermatological: Check for rashes, blisters, or skin peeling.
-
Clinical Pharmacology
- Mechanism of Action
Precise mechanism unknown. Believed to work through selective activation of wake-promoting neurons in hypothalamus.</>
- Pharmacokinetics
Absorption:
Readily absorbed (~90%). Tmax: 2-4 hours
Distribution:
Vd ≈ 0.9 L/kg. Protein binding ~60%
Metabolism:
Hepatic via CYP3A4/2C19
Elimination:
T½: 15 hours. Renal excretion (80%)
-
Indications & Usage
- Narcolepsy
- Obstructive Sleep Apnea (OSA)
- Shift Work Sleep Disorder (SWSD)
-
Contraindications
- Cardiovascular: Avoid in uncontrolled hypertension or heart disease.
- Psychiatric: Not for severe anxiety, psychosis, or bipolar disorder.
- Allergy: Contraindicated in Modafinil hypersensitivity cases.
-
Warnings & Precautions
- Severe Skin Reactions: Stop use if rash, blisters, or peeling occurs
- Allergic Reactions: Seek help for swelling, breathing issues, or hives.
- Psychiatric Symptoms: Discontinue if anxiety, agitation, or hallucinations appear.
-
Dosing & Administration
Narcolepsy
200 mgOnce daily in the morning
Maximum daily dose: 400 mg
Obstructive Sleep Apnea (OSA)
200 mgOnce daily in the morning
Maximum daily dose: 400 mg
Shift Work Disorder (SWD)
200 mgOne hour before work shift
Maximum daily dose: 400 mg
-
Monitoring
- Cardiovascular: Monitor blood pressure and heart rate regularly.
- Psychiatric: Watch for mood changes, anxiety, or hallucinations.
- Dermatological: Check for rashes, blisters, or skin peeling.